:root{color-scheme:light;font-family:system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;color:#173249;background:#f4f8fb}*{box-sizing:border-box}body{margin:0;line-height:1.65}a{color:#086b87}a:focus-visible{outline:3px solid #00879a;outline-offset:3px}.skip{position:absolute;top:-90px;left:8px;background:white;padding:10px;z-index:2}.skip:focus{top:8px}.header{background:#143149;color:white}.header-inner,.wrap,.footer-inner{max-width:1050px;margin:auto;padding:14px 22px}.header-inner{display:flex;align-items:center;justify-content:space-between;gap:18px}.logo{font-size:1.3rem;font-weight:850;color:#e7fffc;text-decoration:none;letter-spacing:.04em}.header-nav{display:flex;gap:16px;flex-wrap:wrap}.header-nav a{color:#dbf8f5;font-size:.89rem}.hero{background:linear-gradient(120deg,#143149,#176d79);color:white;padding:48px 0}.eyebrow{text-transform:uppercase;font-size:.77rem;letter-spacing:.14em;color:#a8f5ed;font-weight:750}.hero h1{font-size:clamp(2rem,4.5vw,3.25rem);max-width:780px;line-height:1.12;margin:13px 0}.hero p{max-width:780px;color:#e0f5f6;font-size:1.06rem}.wrap{padding-top:26px;padding-bottom:56px}.crumb{font-size:.84rem;color:#52677c;padding-bottom:9px}.crumb a{color:#27627a}.grid{display:grid;grid-template-columns:minmax(0,1.8fr) minmax(260px,1fr);gap:24px}.article,.side{background:white;border:1px solid #dce8ee;border-radius:16px;padding:24px}.article p{margin:0 0 18px}.side h2{margin-top:0;font-size:1.13rem}.side ul{padding-left:21px}.side li{margin:11px 0}.note{border-left:4px solid #2498a2;padding:13px 16px;background:#eef8f7;border-radius:5px;margin-top:23px;font-size:.9rem}.other{margin-top:24px}.other h2{font-size:1.17rem}.other-list{display:flex;flex-wrap:wrap;gap:9px}.other-list a{display:inline-block;padding:7px 12px;border:1px solid #cadde5;border-radius:9px;background:white;text-decoration:none}.footer{background:#143149;color:#d0e4ec}.footer-inner{font-size:.85rem}.footer a{color:#c4fff3}@media(max-width:740px){.grid{grid-template-columns:1fr}.header-inner{align-items:flex-start;flex-direction:column}.hero{padding:27px 0}.article,.side{padding:19px}}

/* Enlaces clínicos visibles a nomogramas (Toxicología y portada). */
.me-tox-nomogram-links{display:flex;align-items:center;flex-wrap:wrap;gap:9px;margin:16px 0 22px;padding:14px 16px;border:1px solid #c7dce4;border-radius:12px;background:#f6fafc;color:#173e55}
.me-tox-nomogram-links strong{font-size:15px;width:100%}
.me-tox-nomogram-links span{font-size:13px;line-height:1.55;width:100%;color:#49687c}
.me-tox-nomogram-links a{display:inline-block;border:1px solid #9fbfce;background:#fff;color:#164763;border-radius:8px;padding:8px 10px;text-decoration:none;font-size:13px;font-weight:700}
.me-tox-nomogram-links a:hover,.me-tox-nomogram-links a:focus-visible{background:#e5f3f7;text-decoration:underline}
.me-tox-exposure-field[hidden]{display:none!important}
.me-tox-exposure-form{border:1px solid #c6dbe5;border-radius:10px;padding:12px;margin-top:12px}

.meta-line{font-size:.88rem;color:#52677c;margin-top:-7px}.policy-list{padding-left:22px}.policy-list li{margin:10px 0}.contact-card{border:1px solid #c7dce4;border-radius:12px;background:#f6fafc;padding:18px}.contact-card a{font-weight:750}.updated{display:inline-block;border-radius:999px;background:#e6f4f2;color:#174f59;padding:5px 10px;font-size:.8rem;font-weight:750}