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29px}.eyebrow{font-size:11px;text-transform:uppercase;letter-spacing:.15em;font-weight:800;color:var(--green)}.dot{display:inline-block;width:8px;height:8px;border-radius:50%;background:#00b88d;margin-right:6px}h1{font-size:clamp(34px,5.2vw,64px);letter-spacing:-.06em;line-height:1.13;margin:12px 0 20px;max-width:850px}h1 em{font-weight:650;color:var(--green);font-style:normal}.lead{font-size:16px;color:#4b6970;max-width:800px;margin:0 0 28px;line-height:1.85}.search-form{border-radius:19px;border:1px solid var(--line);padding:20px;background:#fff;box-shadow:0 12px 42px rgba(17,56,63,.05)}.search-form>label{font-size:12px;font-weight:800;display:block;margin-bottom:9px}.search-row{display:flex;gap:10px}.search-row input{flex:1;min-width:0;background:#f8fbfa;border:1px solid #c8dcd8;border-radius:10px;padding:13px 16px;color:var(--ink);font:inherit;font-size:15px;outline-offset:3px}button{font:inherit;cursor:pointer}button:disabled{opacity:.55;cursor:wait}.search-row 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h4{margin:0;font-size:13px;line-height:1.5}.source-row h4 a{color:#155c64;text-decoration:none}.source-row h4 a:hover{text-decoration:underline}.source-meta{display:flex;flex-wrap:wrap;gap:7px;margin:7px 0;font-size:11px;color:#60777b}.tag{border:1px solid #d5e5e0;border-radius:5px;padding:2px 6px;background:#f8fbfa;font-size:10px;font-weight:730;color:#2c655c}.paper-sub{font-size:11px;color:#5c797b}.report-footer{font-size:10px;color:#758787;line-height:1.6;padding:19px 1px}.no-items{padding:30px 5px;font-size:13px;color:#627c80}@media(max-width:750px){.top-inner{gap:12px}.phase{display:none}.shell{padding:0 15px}.hero{padding-top:40px}.search-row{flex-direction:column}.search-row button{width:100%}.notice{display:block}.notice strong{display:block;margin-bottom:6px}.report-grid{display:block}.methods{margin-top:16px}.metrics{grid-template-columns:repeat(2,minmax(0,1fr))}.report-heading{display:block}.report-actions{margin-top:14px}.main-report,.methods,.bibliography{padding:17px}}@media print{@page{size:A4;margin:16mm}html,body{background:#fff!important;color:#101f25!important;font-size:10.5pt}.no-print,.top,.footer{display:none!important}.shell{max-width:none;padding:0}.report{padding:0!important}.report[hidden]{display:none!important}.report-heading{margin:0 0 14pt}.report-kicker{font-size:9pt}.report h2{font-size:21pt}.metrics{grid-template-columns:repeat(4,minmax(0,1fr));gap:5pt}.metric{padding:7pt;border-color:#bbb}.metric strong{font-size:15pt}.report-grid{display:block}.main-report,.methods,.bibliography{border:0;border-radius:0;padding:0}.main-report{margin:12pt 0}.methods{margin:12pt 0;border-top:1px solid #999;padding-top:9pt}.bibliography{margin:12pt 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/* Structured explanatory-disease fiche controls, responsive and print-friendly. */
.research-customization{display:grid;grid-template-columns:1fr 1.2fr;gap:17px;margin-top:17px;padding-top:16px;border-top:1px solid #e4eeeb}
.research-customization label{display:block;font-size:12px;font-weight:800;color:#214a48;margin-bottom:7px}
.research-customization select,.research-customization textarea{display:block;width:100%;border:1px solid #cadcda;background:#f9fcfb;border-radius:10px;padding:11px 12px;color:#183f43;font:inherit;font-size:13px;line-height:1.5;outline-offset:3px}
.research-customization textarea{resize:vertical;min-height:72px;max-height:150px}
.research-customization .optional{font-weight:500;color:#788b90}
.custom-help{font-size:11px;color:#70888b;margin:7px 0 0}
.evidence-point{font-size:13.4px;line-height:1.85;padding:10px 13px;margin:12px 0;border:1px solid #e4eee9;border-left:3px solid #87caba;border-radius:0 8px 8px 0;background:#fdfefd;overflow-wrap:anywhere}
.synthesis-section h4{font-size:17px;line-height:1.4;margin:0 0 10px;color:#184c46}
#report-synthesis>.paper-sub:first-child{background:#eef7f3;padding:10px 12px;border-radius:7px}
.report-actions button:disabled{opacity:.44;cursor:not-allowed}
@media(max-width:750px){.research-customization{grid-template-columns:1fr;gap:13px}.research-customization select{font-size:12.5px}}
@media print{.evidence-point{background:white!important;border-color:#ccc;break-inside:avoid;font-size:10.5pt;line-height:1.6;padding:7pt 8pt}.synthesis-section h4{font-size:13pt}.research-customization{display:none}}

/* Editorial scientific dossier: content-first, not an article-directory export. */
.report{--deep:#143b3d;--accent:#116a62;--muted-ink:#5c7376}
.report-heading{padding:25px 27px 21px;border-radius:17px;background:linear-gradient(120deg,#123e43 0%,#1b5759 100%);color:white;margin-bottom:14px}
.report-heading .report-kicker{color:#9ddfd0;letter-spacing:.16em;font-size:10px}
.report-heading h2{color:#fff;margin:9px 0 8px;letter-spacing:-.055em;font-size:clamp(32px,4.5vw,51px)}
.report-heading .muted{color:#d0e7e3;line-height:1.55;max-width:720px}
.report-heading .report-actions button{background:#e9f7f3;border-color:#e9f7f3;color:#075b54}
.report-heading .report-actions button.outline{border:1px solid rgba(255,255,255,.5);background:transparent;color:#fff}
.report-identity{display:flex;align-items:center;gap:12px;background:#fff;border:1px solid var(--line);padding:11px 17px;border-radius:12px}
.identity-symbol{background:#e6f4f0;border-radius:9px;font-weight:950;font-size:20px;color:#115a51;width:38px;height:38px;display:grid;place-items:center}
.report-identity .identity-label{display:block;font-size:9px;letter-spacing:.16em;font-weight:800;color:#1d786b}
.report-identity strong{font-size:13px;letter-spacing:-.02em}
.identity-version{font-size:10px;letter-spacing:.13em;color:#6b8688;margin-left:auto;font-weight:800}
.report .metrics{grid-template-columns:repeat(4,minmax(0,1fr));gap:7px;margin:10px 0}
.report .metric{padding:9px 12px;background:#fafeff}
.report .metric strong{font-size:20px;color:#16454a}
.report .metric span{font-size:10px}
.report .translation{background:transparent;color:#667c7d;padding:4px 2px;margin:3px 0 16px}
.executive-summary{padding:18px 22px;background:#eaf5f1;border:1px solid #d4ebe1;border-radius:13px;margin-bottom:15px}
.summary-heading{display:flex;align-items:center;justify-content:space-between;gap:15px}
.summary-overline{font-size:11px;letter-spacing:.13em;font-weight:850;color:#135e56}
.summary-state{font-size:10px;color:#46746d;font-weight:800}
.summary-description{margin:6px 0 0;color:#345658;line-height:1.7;font-size:12.5px}
.report-toc{display:flex;flex-wrap:wrap;align-items:center;gap:7px;margin-bottom:17px}
.toc-kicker{color:#5b7a7c;font-size:9px;letter-spacing:.13em;font-weight:900;margin-right:4px}
.toc-link{text-decoration:none;color:#275a59;border:1px solid #d5e7e1;background:#fff;border-radius:6px;padding:5px 9px;font-size:11px}
.report-grid{grid-template-columns:minmax(0,2.5fr) minmax(240px,.8fr);gap:13px}
.main-report,.methods,.bibliography{border-radius:13px;box-shadow:0 4px 20px rgba(16,60,55,.03)}
.main-report{padding:29px 34px}
.main-report>.section-header{padding-bottom:18px;border-bottom:1px solid #dae7e3}
.main-report>.section-header h3{font-size:23px}
.methods{padding:20px 18px}
.synthesis-section{border-top:none;border-bottom:1px solid #dfe9e6;padding:20px 0 26px;margin:0}
.synthesis-section:last-of-type{border-bottom:0}
.chapter-head{display:flex;gap:13px;align-items:flex-start;margin-bottom:13px}
.chapter-index{background:#e2f3eb;color:#0b6757;min-width:38px;height:38px;display:grid;place-items:center;font-size:16px;font-weight:850;border-radius:9px;letter-spacing:-.03em}
.chapter-overline{font-size:9px;letter-spacing:.14em;color:#3d8776;font-weight:850;display:block;margin-bottom:1px}
.chapter-labels h4{font-size:18px;color:#164b4a;line-height:1.28;letter-spacing:-.02em;margin:0}
.synthesis-section .evidence-point{font-size:13.3px;line-height:1.92;color:#2b484b;margin:11px 0;padding:0 0 0 16px;border:0;border-left:2px solid #a3d4c7;border-radius:0;background:transparent;text-align:justify;hyphens:auto}
.synthesis-section .evidence-point+.evidence-point{border-left-color:#dce9e4}
.cite{vertical-align:baseline;font-size:10px;display:inline;padding:1px 4px;color:#075d55;background:#e9f5f0;text-decoration:none;border-radius:3px}
.document-caveat{font-size:11px;line-height:1.65;padding:13px 0;color:#657a79;margin:0}
.evidence-warning{padding:12px 15px;margin:4px 0 16px;border-radius:9px;background:#fff7ec;border:1px solid #e8d7be;color:#704b30;font-size:12px;line-height:1.6}
.bibliography{padding:26px 32px;margin-top:13px}
.bibliography>.section-header{margin-bottom:8px}
.bibliography-hint{font-size:11px;color:#637e7c;margin:4px 0 0}
.source-row{display:grid;grid-template-columns:36px minmax(0,1fr);gap:10px;padding:12px 0;border-color:#e7efeb}
.source-row .source-key{height:29px;font-size:11px}
.source-row h4{line-height:1.46;font-size:12px;margin:0 0 4px}
.source-meta-line{color:#546d6b;font-size:11px;margin:4px 0}
.source-identifier{display:flex;gap:12px;flex-wrap:wrap;font-size:10px;color:#336a61;margin:4px 0}
.extra-sources{border-top:1px solid #e4efeb;padding-top:13px;margin-top:5px}
.extra-sources summary{cursor:pointer;color:#176c61;font-size:12px;font-weight:800}
.extra-sources[hidden]{display:none!important}
@media(max-width:760px){
 .report-heading{padding:21px 19px}
 .report-identity{padding:10px 12px}
 .identity-version{display:none}
 .main-report,.bibliography{padding:18px 18px}
 .report-grid{display:block}
 .report .metrics{grid-template-columns:repeat(2,1fr)}
 .report-toc{overflow-x:auto;flex-wrap:nowrap;padding-bottom:5px}
 .toc-link{white-space:nowrap}
 .synthesis-section .evidence-point{text-align:left}
}
/* A4 journal-like export, without four pages of unused bibliographic cards. */
@media print{
 @page{size:A4;margin:13mm 14mm 16mm}
 html,body{font-size:9.3pt!important;color:#203236!important;background:#fff!important}
 .shell{max-width:none!important;padding:0!important}
 .report{padding:0!important;margin:0!important}
 .report-heading{background:#133f42!important;color:#fff!important;-webkit-print-color-adjust:exact;print-color-adjust:exact;padding:13pt 16pt!important;margin:0 0 9pt!important;border-radius:2pt!important;break-after:avoid}
 .report-heading h2{font-size:26pt!important;line-height:1.1!important;color:#fff!important;margin:5pt 0!important}
 .report-heading .report-kicker{font-size:8pt!important;color:#a8e4d9!important}
 .report-heading .muted{font-size:8.5pt!important;color:#e5f7f2!important;line-height:1.3!important}
 .report-identity{padding:6pt 8pt!important;border-radius:2pt!important;margin-bottom:8pt!important;break-after:avoid}
 .identity-symbol{width:25pt;height:25pt;border-radius:2pt;font-size:14pt}
 .identity-label{font-size:7pt!important}
 .report-identity strong{font-size:9pt!important}
 .identity-version{font-size:7pt!important}
 .report .metrics,.report .translation,.report-toc,.methods,.bibliography-hint,.extra-sources{display:none!important}
 .report-grid{display:block!important}
 .executive-summary{border:1px solid #c5dfd6!important;padding:7pt 10pt!important;margin-bottom:11pt!important;background:#f0f7f3!important;-webkit-print-color-adjust:exact;print-color-adjust:exact;break-after:avoid}
 .summary-overline{font-size:8pt!important}
 .summary-state{font-size:7pt!important}
 .summary-description{font-size:8.2pt!important;line-height:1.4!important;margin:3pt 0!important}
 .main-report,.bibliography{border:0!important;box-shadow:none!important;border-radius:0!important;padding:0!important;margin:0!important}
 .main-report>.section-header{margin:0 0 8pt!important;padding:0 0 6pt!important;border-bottom:1px solid #9dbbb2!important}
 .main-report>.section-header h3{font-size:14pt!important;margin:2pt 0!important}
 .section-header .eyebrow{font-size:7pt!important}
 .synthesis-section{padding:11pt 0 10pt!important;border-bottom:1px solid #dce7e3!important;break-inside:auto;margin:0!important}
 .chapter-head{gap:8pt!important;margin-bottom:6pt!important;break-after:avoid}
 .chapter-index{min-width:27pt;height:27pt;border-radius:3pt;font-size:12pt}
 .chapter-overline{font-size:7pt!important}
 .chapter-labels h4{font-size:13pt!important;margin:0!important}
 .synthesis-section .evidence-point{font-family:Georgia,"Times New Roman",serif!important;font-size:9.3pt!important;line-height:1.63!important;padding:0 0 0 9pt!important;border-left:1.5pt solid #baded0!important;margin:6pt 0 7pt!important;text-align:justify!important;orphans:3;widows:3;break-inside:avoid}
 .cite{font-family:Inter,Arial,sans-serif!important;font-size:7.5pt!important;background:#e7f4ee!important;color:#075e58!important;border:0!important;padding:0 2pt!important}
 .evidence-warning{padding:6pt 8pt!important;margin:0 0 10pt!important;font-size:8pt!important;break-inside:avoid}
 .document-caveat{font-size:7.5pt!important;padding:10pt 0!important;border-top:1px solid #cad9d2!important;margin:5pt 0!important}
 .bibliography{margin-top:13pt!important;padding-top:9pt!important;border-top:2px solid #2f6d61!important;break-before:auto}
 .bibliography .section-header{margin:0 0 6pt!important;break-after:avoid}
 .bibliography .section-header h3{font-size:13pt!important;margin:0}
 .bibliography #report-sources{display:grid!important;grid-template-columns:1fr 1fr!important;column-gap:13pt!important;align-items:start}
 .source-row{grid-template-columns:23pt minmax(0,1fr)!important;gap:5pt!important;padding:4pt 0 5pt!important;border-bottom:1px solid #e6ece8!important;border-top:none!important;break-inside:avoid!important}
 .source-row .source-key{width:22pt;height:18pt;font-size:8pt!important;border-radius:2pt!important}
 .source-row h4{font-size:8.2pt!important;line-height:1.3!important;margin:0 0 2pt!important}
 .source-meta-line{font-size:7.2pt!important;line-height:1.24!important;margin:2pt 0!important}
 .source-identifier{font-size:6.8pt!important;margin:2pt 0!important;gap:4pt!important;word-break:break-word}
 .source-identifier span:last-child{overflow-wrap:anywhere}
 .report-footer{font-size:7pt!important;color:#566e6c!important;border-top:1px solid #bfd2cb!important;padding:7pt 0!important;margin-top:8pt!important}
}

/* Optional public biomedical sources: institutional context and registry.
   Registry entries are never presented as proof of therapeutic efficacy. */
.institutional-context,.trial-register{background:#fff;border:1px solid #dae9e3;border-radius:13px;padding:22px 26px;margin:0 0 16px;box-shadow:0 4px 20px rgba(16,60,55,.03)}
.institutional-context[hidden],.trial-register[hidden]{display:none!important}
.institutional-eyebrow{display:block;color:#23796c;font-weight:850;letter-spacing:.135em;font-size:10px;margin-bottom:7px}
.institutional-context h3,.trial-register h3{font-size:18px;letter-spacing:-.02em;color:#174b46;margin:0 0 12px}
.institutional-content{color:#304d4c;line-height:1.78;font-size:13px;margin:8px 0 12px}
.institutional-source{margin:9px 0;font-size:12px;font-weight:700}
.institutional-source a{color:#0a7164}
.institutional-disclaimer,.trial-disclaimer{font-size:11px;color:#677c79;line-height:1.6;margin:6px 0 10px}
.trial-item{padding:12px 0;border-top:1px solid #e4ede9}
.trial-item-head{display:flex;align-items:flex-start;gap:12px;justify-content:space-between}
.trial-item h4{font-size:12.5px;line-height:1.45;margin:0;color:#234f4b}
.trial-item h4 a{color:#0a6b63;text-decoration:none}
.trial-id{border:1px solid #beddd2;border-radius:5px;padding:3px 6px;font-size:9px;color:#17695e;white-space:nowrap;font-weight:800}
.trial-meta{font-size:11px;color:#637b78;margin:6px 0 0;line-height:1.55}
@media(max-width:760px){.institutional-context,.trial-register{padding:18px 16px}.trial-item-head{display:block}.trial-id{display:inline-block;margin-top:5px}}
@media print{.institutional-context,.trial-register{border:0!important;box-shadow:none!important;margin:0 0 13pt!important;padding:8pt 0!important}.institutional-content{font-size:9pt!important;line-height:1.5!important}.trial-item{break-inside:avoid!important;padding:5pt 0!important}.trial-meta,.institutional-disclaimer,.trial-disclaimer{font-size:8pt!important}.institutional-eyebrow{font-size:8pt!important}}